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Prof.
Marc van Ranst is the head of the Belgian National
SARS Reference Center, and his laboratory is accredited to perform
activities with SARS-CoV in their BSL-3 unit. He is also Director of the
Clinical Virology Laboratory at the University Hospital Gasthuisberg, a
2000-bed teaching hospital. He teaches virology, epidemiology and
bio-informatics courses at the University of Leuven in Belgium, the
University of Kalmar in Sweden, and Charles University in Prague in the
Czech Republic. Prof. Van Ranst is a member of the Belgian High Health
Council, and a cabinet advisor to the Federal Minister of Public Health.
The Rega Institute for Medical Research has extensive experience in the
development and screening of antiviral compounds, and has a successful
track-record of guiding compounds from the laboratory to the market.
Selected
publications Partner 8:
- Vijgen
L., Van Bleyenbergh P., Keyaerts E., Moës E., Demedts M., Lagrou K.,
Peetermans W. and Van Ranst M. “SARS severe acute respiratory
syndrome: een nieuwe longaandoening.” Tijdschrift voor
Geneeskunde 2003, 59:971-977.
- Vijgen
L., Van Bleyenbergh P., Keyaerts E., Demedts M., Lagrou K., Peetermans
W., and Van Ranst M: “SARS (severe acute respiratory syndrome):
een ernstige longaandoening veroorzaakt door een nieuw
coronavirus.” Problemen van Arbeidsgeneeskunde 2004, 39:67-80.
- Vijgen L., Keyaerts E.,
Zlateva K., and Van Ranst M. “Identification of six novel
polymorphisms in the human Coronavirus 229E receptor gene
(aminopeptidase N/CD13).” International Journal of Infectious
Diseases 2004, 8:217-222.
- Keyaerts E., Vijgen L.,
Chen L., Maes P., Hedenstierna G., and Van Ranst M. “Inhibition
of SARS-coronavirus infection in vitro by
S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound.”
International Journal of Infectious Diseases 2004, 8:223-226.
- Keyaerts E., Vijgen L.,
Maes P., Neyts, and Van Ranst M. “In vitro inhibition of severe
acute respiratory syndrome coronavirus by chloroquine.”
Biochemical and Biophysical Research Communications 2004, 323:264-268.
- Vijgen L., Keyaerts E.,
Moës E., Thoelen I., Wollants E., Lemey P., Vandamme AM. and Van Ranst
M. “Complete Genomic Sequence of Human Coronavirus OC43:
Molecular Clock Analysis Suggests a Relatively Recent Zoonotic
Coronavirus Transmission Event.” Journal of Virology 2005, 79:1595-1604.
- Vijgen L., Lemey P.,
Keyaerts E., and Van Ranst M. “Genetic variability of human
respiratory coronavirus OC43” Journal of Virology 2005,
79:3223-3225.
- Moës E., Vijgen L.,
Keyaerts E., Zlateva K., Li S., Maes P., Pyrc K., Berkhout B., van der
Hoek L., and Van Ranst M. “Frequent RT-PCR detection of a novel
human coronavirus NL63 in children hospitalized with RSV-negative
respiratory tract infections in Belgium.” BMC Infectious
Diseases 2005, 5:6.
- Keyaerts E., Vijgen L.
Maes P., Neyts J., and Van Ranst M. “Growth kinetics of
SARS-coronavirus in Vero E6 cells.” Biochemical and Biophysical
Research Communications2005, 329:1147-1151.
- Vijgen L., Keyaerts E.,
Lemey P., Moës E., Li S., and Van Ranst M. “Circulation of
genetically distinct contemporary human coronavirus OC43
strains.” Virology 2005, 337:85-92.
- Vijgen L., Keyaerts E.,
Moës E., Maes P., Duson G., and Van Ranst M. “Development of a
one-step, real-time, quantitative reverse transcriptase PCR assay for
absolute quantification of human coronaviruses OC43 and 229E.”
Journal of Clinical Microbiology 2005, 43:5452-5456.
- Keyaerts E., Vijgen L.,
Maes P., Duson G., Neyts J., and Van Ranst M. “Viral load
quantitation of SARS-coronavirus RNA using a one-step real-time
RT-PCR.” International Journal of Infectious Diseases 2005, In
press.
Prof.dr. Marc
van Ranst
Marc.VanRanst@uz.kuleuven.ac.be
Els Keyaerts
els.keyaerts@uz.kuleuven.ac.be
Leen Vijgen
Leen.vijgen@uz.kuleuven.ac.be
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